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  • If the nerves to the colon do not function normally, the muscles of the colonic wall will not contract properly. The muscles then become stretched and the colon enlarges in diameter. Rather than being pushed into the rectum in a normal manner, fecal material accumulates in the distended colon, resulting in severe constipation called obstipation. This massive enlargement of the colon and the resulting constipation is called megacolon. Megacolon is often treatable using a medical approach but some cases require surgical intervention called subtotal colectomy.

  • Megaesophagus is a disorder in which the esophagus dilates and loses motility. When esophageal motility is decreased or absent, food and liquid accumulate in the esophagus and have difficulty getting into the stomach. Regurgitation is the most common sign of megaesophagus. Weight loss or failure to gain weight, as well as aspiration pneumonia, are also common signs. Treatment is focused on managing the symptoms.

  • Megestrol acetate is given by mouth in the form of a tablet or liquid and is used in dogs or off label in cats to postpone the heat cycle or to treat false pregnancy. It can also be used off label in male dogs to treat prostatic hypertrophy. It should not be used in pregnant pets or pets with uterine disease, diabetes, or breast tumors.

  • Melanomas are cancerous growths of the cells responsible for pigmentation of the skin. They can develop anywhere on the body but those on the toes carry the highest chance for malignancy. They may be painful and you may notice your pet licking at the affected area. Surgery is often the treatment of choice and may be followed up with radiation or chemotherapy.

  • Melatonin is given by mouth or as an implant under the skin and is used to treat sleep and behavior disorders, adrenal disease, and non-allergic hair loss, to suppress the heat cycle, and to improve breeding rates. Give as directed. Side effects are not common but may include sleepiness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

  • Meloxicam is a non-steroidal anti-inflammatory agent used to relieve pain and inflammation in dogs and cats. It is indicated for the treatment of osteoarthritis. Meloxicam has also been used to treat pain associated with surgery.

  • This handout summarizes the many options available to help celebrate your pet’s life and ways to help deal with your grief following the loss of your beloved pet.

  • This handout discusses meningitis, an inflammation of the membranes that cover the brain and spinal cord, in cats. The numerous potential causes, along with the diagnosis, treatment and prognosis of the condition are outlined.

  • Metaldehyde toxicity occurs when a dog (or a cat, less commonly) eats slug bait that contains metaldehyde. Signs of metaldehyde toxicity include vomiting, anxiety, ataxia (due to muscle incoordination), stiffness, muscle tremors, elevated heart rate and respiratory rate, increased salivation, and increased sensitivity to touch. These signs often progress to continuous muscle tremors and seizures. Prognosis is good with aggressive treatment.

  • Methazolamide (brand names Neptazane®, GlaucTabs®, Glaumetax®, MZM) is a carbonic anhydrase inhibitor used off label (extra label) to treat open angle glaucoma in dogs and cats. Do not use in pets that are allergic to it, have significant liver, kidney, or adrenal disease, have electrolyte imbalances, have severe obstructive lung disease, or have closed angle glaucoma.